CDC Warns of Rising Threat of Drug-Resistant Germs

October 28, 2026

The CDC estimates that 19 drug-resistant pathogens cause 9.7 million infections and more than 50,000 deaths annually in the U.S., with resistance continuing to outpace development of new treatments. “The agency considers this problem to be one of our most urgent public health threats,” reports NBC News. From the report: The report is the CDC’s first comprehensive assessment of these drug-resistant pathogens in seven years. […] The new report offers a detailed picture of these threats in the U.S., including a ranking of which are the most urgent concerns, based on the number and severity of infections they cause and how easily preventable or transmissible they are. The ranking also factors in how many treatment options exist and their costs. […] The report estimates that 19 drug-resistant germs cause 9.7 million infections annually in the U.S. Of these, four pathogens are ranked as most worrisome, including the fungus Candida auris and the bacteria that causes gonorrhea, which has become resistant to all but one class of antibiotics used to treat it.

The other two urgent threats, according to the CDC, are the bacteria Acinetobacter and Enterobacterales, both of which are resistant to a class of antibiotics widely considered a “last resort” for patients. In addition, the report adds a new bacteria to the list of “concerning” threats, which are considered less worrisome but still warrant monitoring: neisseria meningitidis, which causes meningococcal disease. The rare but life-threatening illness can be prevented through childhood vaccinations, but the bacteria that causes it is slowly developing a resistance to penicillin and another antibiotic called ciprofloxacin.

The report also offers some good news: The CDC determined that the bacteria Clostridioides difficile, or “C. diff,” which causes diarrhea and inflammation of the colon and can be deadly, is causing fewer cases year over year. The agency downgraded it to a serious threat, whereas it was categorized as urgent in the prior version of the report, which came out in 2019.